A comparative study of the effects of retinol and retinoic acid on histological, molecular, and clinical properties of human skin. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. It’s also a good idea to do a “use test.” This is when you put a small amount of the product on your inner forearm for several days to make sure you don’t have a reaction prior to applying it all over your face To reduce the risk of irritation or allergic reaction, talk with a dermatologist about the specific OTC retinol brand you’re considering. ![]() Most OTC retinol products are safe to use as directed, but there are some common side effects that can cause irritation in the short term.
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